Take a look at the Quick Commands Reference (or whatever JAWS calls it, and it will be obvious) in the JAWS Help menu. I don't know of a single JAWS command that does not have both a desktop (or laptop that has a number pad, which one generally uses desktop keyboard layout with) and a laptop layout command.
If you intend to use this laptop in "full portable" mode you'll want to be using the laptop keyboard layout and the corresponding keystrokes for that layout. You can also, of course, plug in an external full keyboard and use typical desktop keyboard layout with JAWS as well, but if you don't have it handy you'll need to know the laptop layout specific sequences.
Brian - Windows 10 Pro, 64-Bit, Version 2004, Build 19041
The purpose of education is not to validate ignorance but to overcome it.