I endorse George’s recommendation of Schwab. Some years ago, they did considerable work on accessibility with me and another JAWS user, and they remain responsive.

Another JAWS user is an advocate of Fidelity. As a broker himself, he has some influence over Fidelity’s practices.

You may know that e-Trade is in the process of being purchased by Morgan Stanley. I’m not sure how much priority accessibility will receive during a pending acquisition.

I’ve had accessibility issues with Vanguard in the past, but I haven’t been on that website for a long time.