Well, I wouldn’t. There are a few levels of uAC; I wouldn’t just say yes to whatever it asks, it’s good that it lets you know what programmes are attempting to do admin tasks and I’m certainly glad (after having disabled it for a time myself) that extra layer of security is there. User discretion is a good thing.

The 33% setting doesn’t seem to work with jAWS or nVDA in the sense that you can’t read what app is attempting to gain access. Weird. I have mine set to 66% (I think it is) and the difference isnt’ appreciable, and now I can read the uAC screen properly. Not sure about the “secure uap” window the OP mentions – have you tried a google search to see what this might be?