One of the first things I do for my clients who are screen reader users is to remove the loathsome "Protected View" default from MS-Office programs. It's the second thing I do for my sighted clients.
This is an anachronism and a hold over from the days before virtually every antivirus/security suite in existence scans attachments being downloaded as a part of that process.
If you'd like to do the same:
Brian - Windows 10 Home, 64-Bit, Version 1803, Build 17134
A great deal of intelligence can be invested in ignorance when the need for illusion is deep.
~ Saul Bellow, To Jerusalem and Back