Absolutely true and correct. There is the occasional website that not only plays with a given screen reader better than another, but a given web browser better than another, and one can always force its opening via shortcut by specifying the command line arguments for the browser preferred for the exception instance.
I use bookmarks a lot more than desktop shortcuts when it comes to web-related material, but there have been occasions where I have put a web shortcut on the desktop.
These days I don't use bookmarks except for Firefox and even then only for collections of links that I want to open all at once in their own tabs without having to don them one by one.
Brian - Windows 10 Home, 64-Bit, Version 1803, Build 17134
The real art of conversation is not only to say the right thing in the right place but to leave unsaid the wrong thing at the tempting moment.
~ Dorothy Nevill